10147-69-0Relevant articles and documents
Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents
Elkamhawy, Ahmed,Kim, Nam youn,Hassan, Ahmed H.E.,Park, Jung-eun,Paik, Sora,Yang, Jeong-Eun,Oh, Kwang-Seok,Lee, Byung Ho,Lee, Mi Young,Shin, Kye Jung,Pae, Ae Nim,Lee, Kyung-Tae,Roh, Eun Joo
, (2020)
Selective kinase inhibitors development is a cumbersome task because of ATP binding sites similarities across kinases. On contrast, irreversible allosteric covalent inhibition offers opportunity to develop novel selective kinase inhibitors. Previously, we
A highly selective and sensitive fluorescent chemosensor for Fe 3+ in physiological aqueous solution
Hua, Jun,Wang, Yan-Guang
, p. 98 - 99 (2005)
A novel fluorescent chemosensor in which two aza-18-crown-6 moieties are linked to a coumarin fluorophore has been synthesized for sensing Fe 3+. The selective fluorescence enhancement was observed upon binding Fe3+ at physiological
Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics
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Paragraph 0213, (2020/02/19)
Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.