10148-68-2 Usage
Description
(2S,3S)-2-AMINO-3-HYDROXY-HEXANOIC ACID, also known as (2S,3S)-3-Hydroxynorleucine, is an organic compound with the molecular formula C6H13NO3. It is a chiral molecule with two stereocenters, both in the S configuration. (2S,3S)-2-AMINO-3-HYDROXY-HEXANOIC ACID is an analogue of DL-6-Hydroxy Norleucine (H948855) and is characterized by its amino and hydroxy functional groups, which contribute to its potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
(2S,3S)-2-AMINO-3-HYDROXY-HEXANOIC ACID is used as an intermediate for the synthesis of antiviral and antihypertensive drugs. Its unique structure allows it to serve as a building block for the development of new medications targeting viral infections and high blood pressure.
Used in Chemical Synthesis:
(2S,3S)-2-AMINO-3-HYDROXY-HEXANOIC ACID can be utilized as a chiral synthon in the synthesis of various chiral compounds. Its specific stereochemistry makes it a valuable starting material for the preparation of enantiomerically pure molecules with potential applications in the pharmaceutical, agrochemical, and fragrance industries.
Used in Research and Development:
As a compound with distinct stereochemistry, (2S,3S)-2-AMINO-3-HYDROXY-HEXANOIC ACID can be employed in research and development for studying the effects of stereochemistry on biological activity, pharmacokinetics, and pharmacodynamics. This knowledge can be applied to optimize drug design and improve the efficacy and safety of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 10148-68-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,4 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 10148-68:
(7*1)+(6*0)+(5*1)+(4*4)+(3*8)+(2*6)+(1*8)=72
72 % 10 = 2
So 10148-68-2 is a valid CAS Registry Number.
10148-68-2Relevant articles and documents
Synthesis of γ-halogenated and long-chain β-hydroxy-α-amino acids and 2-amino-1,3-diols using threonine aldolases
Steinreiber, Johannes,Fesko, Kateryna,Mayer, Clemens,Reisinger, Christoph,Schürmann, Martin,Griengl, Herfried
, p. 8088 - 8093 (2007)
The l- and d-threonine aldolase catalyzed formation of γ-halogenated and long-chain l- and d-3-alkylserine-derivatives 1-12, respectively, was shown starting from glycine and halogenated C2- or C4-C12 aldehydes. lTA from Pseudomonas putida accepted all tested aldehydes with strongly varying diastereoselectivity (de up to 93%). Only aldehydes smaller than decanal were converted by dTA from Alcaligenes xylosoxidans with good selectivities (de up to 73%). Utilizing isobutanal enantio- and diastereopure d-syn-2-amino-3-hydroxy-4-methylpentanoic acid was obtained (ee>99%, de>95%), which was converted to the corresponding 2-amino-1,3-diol.
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Niimura,Y.,Hatanaka,S.-I.
, p. 175 - 178 (1974)
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ASYMMETRIC ALDOL REACTIONS USING BORON ENOLATES OF CHIRAL OXAZINONES, SYNTHESIS OF L-ALLO-THREONINE
Reno, Daniel S.,Lotz, Bruce T.,Miller, Marvin J.
, p. 827 - 830 (2007/10/02)
The boron enolate of oxazinone 1 was allowed to react with acetaldehyde, butanal, and 2-methylpropanal.The reaction proceeded stereoselectively, and in the reaction with acetaldehyde, the reaction afforded a precursor to L-allo-threonine.
