1014990-30-7

Basic information

• Product Name: 4-(2-[methyl(pyridine-2-yl)amino]ethoxy)benzonitrile
• Synonyms: 4-(2-[methyl(pyridine-2-yl)amino]ethoxy)benzonitrile
• CAS NO: 1014990-30-7
• Molecular Weight: 253.304
• Mol File: 1014990-30-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-[methyl(pyridine-2-yl)amino]ethoxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-[methyl(pyridine-2-yl)amino]ethoxy)benzonitrile(1014990-30-7)
• EPA Substance Registry System: 4-(2-[methyl(pyridine-2-yl)amino]ethoxy)benzonitrile(1014990-30-7)

Safety Data

• Hazardous Substances Data: 1014990-30-7(Hazardous Substances Data)

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 122321-04-4 2-(N-methyl-N-(pyridin-2-yl)amino)ethanol 

Downstream Products

• 122321-03-3 4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzaldehyde 

Relevant articles and documents

An improved process for the preparation of 4-[2-(methyl-2-pyridinylamino) ethoxy] benzaldehyde, an intermediate for the preparation of rosiglitazone

The invention relates to an improved process for the preparation of 4-[2-(methyl-2-pyridinylamino)ethoxy]-benzaldehyde via 4-[2-(methyl-2-pyridinylamino).ethoxy]-benzonitrile. The process of preparation of 4-[2-(methyl-2-pyridinylamino)ethoxy]-benzaldehyde comprises: (a) Reacting 2[methyl(pyridine-2-yl)amino]ethanol with 4-halobenzonitrile using a base in a solvent, to give 4-(2-[methyl(pyridine-2-yl)amino]ethoxy)benzonitrile, (b) reacting a solution of 4-(2-[methyl(pyridine-2-yl)amino]ethoxy)benzonitrile in formic acid with Raney nickel in water ,to give 4-[2-(methyl-2-pyridinylamino)ethoxy]-benzaldehyde.