1015255-46-5 Usage
Description
(S)-2-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylaminopropionic acid methyl ester is a complex organic compound with a unique molecular structure. It is characterized by its chiral centers and various functional groups, which contribute to its potential applications in different fields.
Uses
Used in Pharmaceutical Industry:
(S)-2-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylaminopropionic acid methyl ester is used as a potential therapeutic agent for the treatment of Hepatitis C Virus. Its unique structure allows it to target specific viral enzymes, inhibiting their activity and thus helping to combat the virus.
Used in Chemical Synthesis:
In the field of chemical synthesis, (S)-2-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylaminopropionic acid methyl ester can be used as a key intermediate or building block in the synthesis of other complex molecules, such as pharmaceuticals, agrochemicals, or advanced materials.
Used in Research and Development:
Due to its unique structure and potential applications, (S)-2-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylaminopropionic acid methyl ester can be utilized in research and development for the discovery of new drugs, materials, or chemical processes. Its synthesis and properties can provide valuable insights into the design and development of novel compounds with specific applications.
Used in Quality Control and Impurity Analysis:
As an impurity of Sofosbuvir (P839640), (S)-2-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylaminopropionic acid methyl ester can be used in quality control and impurity analysis of pharmaceutical products. Understanding and controlling the presence of such impurities is crucial for ensuring the safety, efficacy, and quality of the final drug product.
Check Digit Verification of cas no
The CAS Registry Mumber 1015255-46-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,5,2,5 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1015255-46:
(9*1)+(8*0)+(7*1)+(6*5)+(5*2)+(4*5)+(3*5)+(2*4)+(1*6)=105
105 % 10 = 5
So 1015255-46-5 is a valid CAS Registry Number.
1015255-46-5Relevant articles and documents
The mechanism of action of β-D-2′-deoxy-2′-fluoro- 2′-C-methylcytidine involves a second metabolic pathway leading to β-D-2′-deoxy-2′-fluoro-2′-C-methyluridine 5′-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
Murakami, Eisuke,Niu, Congrong,Bao, Haiying,Micolochick Steuer, Holly M.,Whitaker, Tony,Nachman, Tammy,Sofia, Michael A.,Wang, Peiyuan,Otto, Michael J.,Furman, Phillip A.
, p. 458 - 464 (2008)
β-D-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) is a potent inhibitor of hepatitis C virus (HCV) RNA replication in an HCV replicon assay. The 5′-triphosphate of PSI-6130 is a competitive inhibitor of the HCV RNA-dependent RNA polymerase (RdRp) and
Discovery of a luoro-2′-β- C -methyluridine Nucleotide Prodrug (PSI-7977) for the treatment of hepatitis C virus
Sofia, Michael J.,Bao, Donghui,Chang, Wonsuk,Du, Jinfa,Nagarathnam, Dhanapalan,Rachakonda, Suguna,Reddy, P. Ganapati,Ross, Bruce S.,Wang, Peiyuan,Zhang, Hai-Ren,Bansal, Shalini,Espiritu, Christine,Keilman, Meg,Lam, Angela M.,Steuer, Holly M. Micolochick,Niu, Congrong,Otto, Michael J.,Furman, Phillip A.
experimental part, p. 7202 - 7218 (2010/12/25)
Hepatitis C virus (HCV) is a global health problem requiring novel approaches for effective treatment of this disease. The HCV NS5B polymerase has been demonstrated to be a viable target for the development of HCV therapies. β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl nucleosides are selective inhibitors of the HCV NS5B polymerase and have demonstrated potent activity in the clinic. Phosphoramidate prodrugs of the 5′-phosphate derivative of the β-d-2′-deoxy-2′-α- fluoro-2′-β-C-methyluridine nucleoside were prepared and showed significant potency in the HCV subgenomic replicon assay (1 μM) and produced high levels of triphosphate 6 in primary hepatocytes and in the livers of rats, dogs, and monkeys when administered in vivo. The single diastereomer 51 of diastereomeric mixture 14 was crystallized, and an X-ray structure was determined establishing the phosphoramidate stereochemistry as Sp, thus correlating for the first time the stereochemistry of a phosphoramidate prodrug with biological activity. 51 (PSI-7977) was selected as a clinical development candidate.
