1015763-46-8

Basic information

• Product Name: C₁₇H₂₄O₄
• Synonyms: C₁₇H₂₄O₄
• CAS NO: 1015763-46-8
• Molecular Weight: 292.375
• Mol File: 1015763-46-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₄O₄(1015763-46-8)
• EPA Substance Registry System: C₁₇H₂₄O₄(1015763-46-8)

Safety Data

• Hazardous Substances Data: 1015763-46-8(Hazardous Substances Data)

Upstream product

• 950-99-2 2,2,5,7,8-pentamethylchroman-6-ol 
• 13398-11-3 iodomethyl acetate 

Relevant articles and documents

Reaction of α-(n-alkylcarbonyloxy)alkyl (ACOA) halides with 4-hydroxyacetanilide and 2,2,5,7,8-pentamethyl-6-chromanol: The effect of steric hindrance on reaction path

A convenient synthesis of α-(n-alkylcarbonyloxy)alkyl (ACOA) iodides has been developed and a homologous series of n-alkylcarbonyloxymethyl (ACOM) iodides have been used to alkylate 4-hydroxyacetanilide (acetaminophen, APAP), a sterically unhindered phenol, and a sterically hindered phenol (2,2,5,7,8-pentamethyl-6-chromanol). Steric hindrance was not a significant factor in the ratio of acylated (Path b) to alkylated (Path a) for these reactions. Given the reported toxicity associated with sterically hindered ACOM prodrugs, n-alkyl ACOM and ACOA promoieties present themselves as viable alternatives to the more commonly used pivalate-based derivatives. Georg Thieme Verlag Stuttgart.