1015936-63-6

Basic information

• Product Name: 2-BROMO-1-(1,3-DIMETHYL-1H-PYRAZOL-5-YL)ETHANONE
• Synonyms: 2-BROMO-1-(1,3-DIMETHYL-1H-PYRAZOL-5-YL)ETHANONE;2-Bromo-1-(1,3-dimethyl-1H-pyrazol-5-yl)ethanone ,90%;2-broMo-1-(1,3-diMethyl-1h-pyrazole-5-yl)ethanone
• CAS NO: 1015936-63-6
• Molecular Formula: C7H9BrN2O
• Molecular Weight: 217.06
• Product Categories: Heterocycle
• Mol File: 1015936-63-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 291.7±25.0 °C(Predicted)
• Appearance: white powder
• Density: 1.54±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 0.42±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-1-(1,3-DIMETHYL-1H-PYRAZOL-5-YL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(1,3-DIMETHYL-1H-PYRAZOL-5-YL)ETHANONE(1015936-63-6)
• EPA Substance Registry System: 2-BROMO-1-(1,3-DIMETHYL-1H-PYRAZOL-5-YL)ETHANONE(1015936-63-6)

Safety Data

• Hazardous Substances Data: 1015936-63-6(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

Upstream product

• 87375-38-0 5-acetyl-1,3-dimethylpyrazole 

Relevant articles and documents

Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain

A novel series of (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives were identified as selective transient receptor potential vanilloid 4 (TRPV4) channel antagonist and showed analgesic effect in Freund's Complete Adjuvant (FCA) induced mechanical hyperalgesia model in guinea pig and rat. Modification of right part based on the compound 16d which was disclosed in our previous communication led to the identification of compound 26i as a flagship compound. In this paper, we described the details about design, synthesis and structure-activity relationship (SAR) analysis at right and left part of these derivatives (Fig. 1).