101594-21-2Relevant articles and documents
Enantioselective Nickel-Catalyzed anti-Carbometallative Cyclizations of Alkynyl Electrophiles Enabled by Reversible Alkenylnickel E/Z Isomerization
Clarke, Christopher,Incerti-Pradillos, Celia A.,Lam, Hon Wai
, p. 8068 - 8071 (2016)
Nickel-catalyzed additions of arylboronic acids to alkynes, followed by enantioselective cyclizations of the alkenylnickel species onto tethered ketones or enones, are reported. These reactions are reliant upon the formal anti-carbonickelation of the alkyne, which is postulated to occur by the reversible E/Z isomerization of an alkenylnickel species.
Cobalt-catalysed synthesis of highly substituted styrene derivatives via arylzincation of alkynes
Corpet, Martin,Gosmini, Corinne
, p. 11561 - 11563,3 (2012/12/12)
A new two-step procedure was developed by carbozincation of internal and terminal alkynes to synthesise highly functionalised vinylzinc bromides. Various tri and tetrasubstituted alkenes were prepared in moderate to good yields under mild reaction conditions in a stereo-selective manner. This methodology represents an interesting alternative to previously known methods. This journal is
Iron-catalyzed arylmagnesiation of aryl(alkyl)acetylenes in the presence of an N-heterocyclic carbene ligand
Yamagami, Takafumi,Shintani, Ryo,Shirakawa, Eiji,Hayashi, Tamio
, p. 1045 - 1048 (2007/10/03)
(Chemical Equation Presented) Addition of arylmagnesium bromides to aryl(alkyl)acetylenes proceeded in the presence of an iron catalyst and a N-heterocyclic carbene ligand to give high yields of the corresponding alkenylmagnesium reagents, which were transformed into tetrasubstituted alkenes by subsequent treatment with electrophiles.
