101594-59-6

Basic information

• Product Name: 3-methyl-2-phenoxy-1-phenylbutan-1-one
• Synonyms: 3-methyl-2-phenoxy-1-phenylbutan-1-one
• CAS NO: 101594-59-6
• Molecular Weight: 254.329
• Mol File: 101594-59-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-methyl-2-phenoxy-1-phenylbutan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-2-phenoxy-1-phenylbutan-1-one(101594-59-6)
• EPA Substance Registry System: 3-methyl-2-phenoxy-1-phenylbutan-1-one(101594-59-6)

Safety Data

• Hazardous Substances Data: 101594-59-6(Hazardous Substances Data)

Upstream product

• 147749-67-5 2-bromo-3-methyl-1-phenylbutan-1-one 
• 108-95-2 phenol 
• 582-62-7 3-methyl-1-phenylbutan-1-one 

Relevant articles and documents

Aldol-Tishchenko Reaction of α-Oxy Ketones: Diastereoselective Synthesis of 1,2,3-Triol Derivatives

α-Oxy ketones, easily accessible by conventional routes, can be selectively deprotonated generating an enolate intermediate, which upon treatment with paraformaldehyde undergoes an aldol-Tishchenko reaction, leading to relevant 1,2,3-triol fragments in a totally diastereoselective manner. The excellent stereocontrol in the generation of a quaternary stereocenter is attributed to stereoelectronic effects in the Evans intermediate. This methodology allows overcoming some limitations of our previously reported strategy, based on the reaction of α-lithiobenzyl ethers with esters and paraformaldehyde, broadening the scope of the obtained polyols. Synthetic applications of this process include the preparation of a new dilignol model and some functionalized oxetanes.