101620-05-7

Basic information

• Product Name: 2,4-Pentadienoic acid, 5-(3,4,5-trimethoxyphenyl)-, ethyl ester, (2E,4E)-
• CAS NO: 101620-05-7
• Molecular Formula: C16H20O5
• Molecular Weight: 292.332
• Mol File: 101620-05-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 431.8±45.0 °C(Predicted)
• Density: 1.100±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2,4-Pentadienoic acid, 5-(3,4,5-trimethoxyphenyl)-, ethyl ester, (2E,4E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pentadienoic acid, 5-(3,4,5-trimethoxyphenyl)-, ethyl ester, (2E,4E)-(101620-05-7)
• EPA Substance Registry System: 2,4-Pentadienoic acid, 5-(3,4,5-trimethoxyphenyl)-, ethyl ester, (2E,4E)-(101620-05-7)

Safety Data

• Hazardous Substances Data: 101620-05-7(Hazardous Substances Data)

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 36266-40-7 1-(3,4,5-trimethoxyhenyl)ethanol 
• 71277-13-9 3,4,5-trimethoxycinnamaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 42516-28-9 ethyl (2E)-4-(diethoxyphosphoryl)crotonate 

Downstream Products

• 203722-02-5 (E,E)-5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl chloride 
• 28010-23-3 (E,E)-5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoic acid 

Relevant articles and documents

Synthesis of dihydronaphthalenes via aryne Diels-Alder reactions: Scope and diastereoselectivity

Novel aryne Diels-Alder reactions with functionalized acyclic dienes are reported. These give useful cis-substituted dihydronaphthalene building blocks in good yield which are not easily accessible via other means, as demonstrated in the synthesis of sert

(2E,4E)-N-(4-(1H-indol-3-yl)piperidin-1-yl)alkyl-5-(substituted phenyl)-2,4-pentadienamides as antiallergic agents with antihistaminic and anti slow-reacting substance (SRS) activities

As an extension of our study aiming to discover a novel compound with dual activities against histamine and slow-reacting substance (SRS), we synthesized two types of indolylpiperidine derivatives, 3 and 4-20. Testing for in vivo antianaphylactic activity and for in vitro anti-SRS activity revealed that (2E,4E)-5-(3,5-dimethoxy-4-hydroxyphenyl)-N-(2-(4-(1H-indol-3-yl)piper idin-1-yl)ethyl)-2,4-pentadienamide (11) exhibited potent dual activities with ED50 = 0.89 mg/kg and IC50 = 1.43 μM, respectively. However, the plasma concentration of unchanged 11 was very low when administered orally in guinea pigs. This result can be explained by fast formation of a glucuronic acid conjugate.