101620-15-9

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[2-(diphenylmethoxy)ethyl]-
• CAS NO: 101620-15-9
• Molecular Formula: C23H19NO3
• Molecular Weight: 357.409
• Mol File: 101620-15-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[2-(diphenylmethoxy)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[2-(diphenylmethoxy)ethyl]-(101620-15-9)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[2-(diphenylmethoxy)ethyl]-(101620-15-9)

Safety Data

• Hazardous Substances Data: 101620-15-9(Hazardous Substances Data)

Usage

Structure

The chemical compound contains the isoindole-1,3(2H)-dione structure.

Molecular weight

383.44 g/mol.

Physical form

White to off-white solid.

Solubility

Sparingly soluble in water and soluble in organic solvents.

Potential applications

May have potential applications in the pharmaceutical and agrochemical industries.

Use as building block

Can be used as a building block for the synthesis of various compounds.

Further research needed

Further research and evaluation of its properties and potential uses are necessary.

Upstream product

• 91-01-0 1,1-Diphenylmethanol 
• 136918-14-4 phthalimide 
• 6305-20-0 2-bromoethyl benzhydryl ether 

Downstream Products

• 17349-94-9 2-{[(diphenyl)methyl]oxy}ethylamine 

Relevant articles and documents

Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport

2-Aminoethyl diphenylborinate (2-APB) is a known modulator of the IP 3 receptor, the calcium ATPase SERCA, the calcium release-activated calcium channel Orai and TRP channels. More recently, it was shown that 2-APB is an efficient inhibitor of the epithelial calcium channel TRPV6 which is overexpressed in prostate cancer. We have conducted a structure-activity relationship study of 2-APB congeners to understand their inhibitory mode of action on TRPV6. Whereas modifying the aminoethyl moiety did not significantly change TRPV6 inhibition, substitution of the phenyl rings of 2-APB did. Our data show that the diaryl borinate moiety is required for biological activity and that the substitution pattern of the aryl rings can influence TRPV6 versus SOCE inhibition. We have also discovered that 2-APB is hydrolyzed and transesterified within minutes in solution.