101629-95-2

Basic information

• Product Name: 4-Hydroxy-6-methyl-2-methylene-heptanoic acid ((S)-1-benzyl-propyl)-amide
• Synonyms: 4-Hydroxy-6-methyl-2-methylene-heptanoic acid ((S)-1-benzyl-propyl)-amide
• CAS NO: 101629-95-2
• Molecular Weight: 303.445
• Mol File: 101629-95-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Hydroxy-6-methyl-2-methylene-heptanoic acid ((S)-1-benzyl-propyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-6-methyl-2-methylene-heptanoic acid ((S)-1-benzyl-propyl)-amide(101629-95-2)
• EPA Substance Registry System: 4-Hydroxy-6-methyl-2-methylene-heptanoic acid ((S)-1-benzyl-propyl)-amide(101629-95-2)

Safety Data

• Hazardous Substances Data: 101629-95-2(Hazardous Substances Data)

Upstream product

• 101629-94-1 N-(1-benzylpropyl)-2<(tributylstannyl)methyl>propenamide 
• 590-86-3 isovaleraldehyde 

Relevant articles and documents

Asymmetric Synthesis of α-Methylene-γ-butyrolactones Using Chiral N-Monosubstituted 2-propenamides

α-Methylene-γ-butyrolactones were prepared in high yields on treatment of N-monosubstituted 2-propenamides with aldehydes in the presence of a Lewis acid followed by acidic hydrolysis of the resulting γ-hydroxy amides.Asymmetric synthesis of α-methylene-γ-butyrolactones was investigated by using a variety of chiral 2-propenamides derived from optically active amines.Reaction of N--2-propenamide or its antipode with aldehydes in the presence of 4 equiv of TiCl4 gave, after hydrolysis, α-methylene lactones in an enantiometric excess of as high as 80percent.Optically pure 3-methylene-2-pyrrolidinones were obtained in excellent yields by a one-pot sequence starting with the γ-hydroxy amides.