1016543-96-6Relevant articles and documents
Identification of CKD-516: A potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors
Lee, Jaekwang,Kim, Soo Jin,Choi, Hojin,Kim, Young Hoon,Lim, In Taek,Yang, Hyun-Mo,Lee, Chang Sik,Kang, Hee Ryong,Ahn, Soon Kil,Moon, Seung Kee,Kim, Dal-Hyun,Lee, Sungsook,Choi, Nam Song,Lee, Kyung Joo
experimental part, p. 6337 - 6354 (2010/10/21)
Tubulin polymerization inhibitors had emerged as one of promising anticancer therapeutics because of their dual mechanism of action, i.e. apoptosis by cell-cycle arrest and VDA, vascular disrupting agent. VDAs are believed to be more efficient, less toxic
BENZOPHENONE DERIVATIVES USEFUL FOR INHIBITING FORMATION OF MICROTUBULE
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Page/Page column 113, (2008/06/13)
Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition containing the same, and a use of the composition as therapeutic drugs. The benzophenone derivatives have an inhibition activity of microtubule formation and can be used to treat a normal proliferative state of a malignant tumor by killing the actively proliferating cells.