10166-05-9Relevant articles and documents
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Badr,M.Z.A.,El-Sherief,H.A.H.
, p. 3831 - 3836 (1975)
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Synthesis of isoquinolines and pyridines via palladium-catalysed iminoannulation of allenes
Diederen, Jeroen J. H.,Sinkeldam, Rene W.,Fruehauf, Hans-W,Hiemstra, Henk,Vrieze, Kees
, p. 4255 - 4258 (1999)
Various isoquinolines and pyridines were prepared from aryl- and vinyl halides by a method which involves insertion of an allene into the Pd-C bond and intramolecular nucleophilic attack of the imine.
Microwave-Assisted Palladium-Catalyzed Reductive Cyclization/Ring-Opening/Aromatization Cascade of Oxazolidines to Isoquinolines
Xu, Xianjun,Feng, Huangdi,Van Der Eycken, Erik V.
, p. 6578 - 6582 (2021/09/02)
An efficient palladium-catalyzed reaction of N-propargyl oxazolidines for the construction of 4-substituted isoquinolines under microwave irradiation is developed. This transformation proceeds through a sequential palladium-catalyzed reductive cyclization/ring-opening/aromatization cascade via C-O and C-N bond cleavages of the oxazolidine ring. The practical value of this method has also been explored by conducting a millimole-scale reaction, as well as by transforming the isoquinoline into a key intermediate for the synthesis of a lamellarin analogue.