1016696-74-4Relevant articles and documents
Synthetic method 2 - n-propyl -4 - methyl -6 - (1 -methylbenzimidazole -2 -yl) benzimidazole (by machine translation)
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, (2020/10/04)
The invention relates to the technical field of synthesis of medical intermediates, and discloses a synthesis method of 2 - n-propyl -4 - methyl -6 - (1 -methylbenzimidazole -2 -yl) benzimidazole; S1: a condensation closed loop is obtained; and the reaction temperature is controlled to 3 - and the intermediate IV is N - [-4 - methyl -5 - (40 - 110 °C-methylbenzimidazole) 2 -nitrophenyl]-butylamide; S2: a reduction ring; and the preparation method comprises the following steps: S3: condensation ring-ring synthesis and intermediate IV of -4 -propyl -4 - 1 -6 - methyl 1 - S4 -2 - (-6 -methylbenzimidazol 2 -yl) benzimidazole -2 . 2 - N-propyl -4 - methyl -6 - (1 -methylbenzimidazole -2 -yl) benzimidazole is higher in purity, reduced in impurities and high in yield. (by machine translation)