1016804-06-0

Basic information

• Product Name: 7-broMo-3,4-dihydro-2H-chroMen-4-aMine
• Synonyms: 7-broMo-3,4-dihydro-2H-chroMen-4-aMine;7-BROMOCHROMAN-4-AMINE HCL;7-BROMOCHROMAN-4-AMINE
• CAS NO: 1016804-06-0
• Molecular Formula: C9H10BrNO
• Molecular Weight: 228.0858
• Mol File: 1016804-06-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-broMo-3,4-dihydro-2H-chroMen-4-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-broMo-3,4-dihydro-2H-chroMen-4-aMine(1016804-06-0)
• EPA Substance Registry System: 7-broMo-3,4-dihydro-2H-chroMen-4-aMine(1016804-06-0)

Safety Data

• Hazardous Substances Data: 1016804-06-0(Hazardous Substances Data)

Usage

General Description

7-bromo-3,4-dihydro-2H-chromen-4-amine is a chemical compound with a molecular formula C10H10BrNO that belongs to the class of chromen-4-amine derivatives. It is a brominated derivative of chromen amine and has a 3,4-dihydro-2H-chromen backbone. 7-broMo-3,4-dihydro-2H-chroMen-4-aMine has potential pharmacological properties and has been used in various medicinal and research applications. It may have potential use in the development of new drugs or as a tool compound for studying biological pathways. Additionally, its bromine substituent may provide unique reactivity and properties that can be exploited for different chemical and biological applications.

Upstream product

• 18442-22-3 7-Bromo-2,3-dihydro-4H-chromen-4-one 
• 18385-82-5 7-bromochroman-4-ol 
• 1392072-40-0 (rac)-4-azido-7-bromochroman 
• 27407-19-8 7-bromochroman-4-one oxime 

Relevant articles and documents

NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST GLUCOSYLCERAMIDE SYNTHASE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESSES FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

The present invention provides a novel compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof. The compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

SUBSTITUTED CHROMANES AND METHOD OF USE

The invention provides for compounds of formula (I), wherein R1, X, Y, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, and R" have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sj?gren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 and n are as described herein, compositions including the compounds and methods of using the compounds.