1016978-03-2Relevant articles and documents
Synthesis and testing of chromogenic phenoxazinone substrates for β-alanyl aminopeptidase
Zaytsev, Andrey V.,Anderson, Rosaleen J.,Bedernjak, Alexandre,Groundwater, Paul W.,Huang, Yongxue,Perry, John D.,Orenga, Sylvain,Roger-Dalbert, Celine,James, Arthur
, p. XX682-692 (2008)
Novel 7-N-(β-alanyl)aminophenoxazin-3-one salts 27a-d have been synthesized and tested as chromogenic substrates for β-alanyl aminopeptidase, which is present in Pseudomonas aeruginosa, the most common respiratory pathogen in patients with cystic fibrosis. The biological results show that 7-N-(β-alanyl)amino-1-pentylphenoxazin-3-one trifluoroacetate salt 27a is a chromogenic substrate for this bacterium, with a low degree of diffusion in nutrient media for growing bacterial cultures and a bright red colour, making it easily distinguishable from the agar background. This journal is The Royal Society of Chemistry.