1017054-13-5

Basic information

• Product Name: C₁₀H₉BrFNO
• Synonyms: C₁₀H₉BrFNO
• CAS NO: 1017054-13-5
• Molecular Weight: 258.09
• Mol File: 1017054-13-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₀H₉BrFNO(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₉BrFNO(1017054-13-5)
• EPA Substance Registry System: C₁₀H₉BrFNO(1017054-13-5)

Safety Data

• Hazardous Substances Data: 1017054-13-5(Hazardous Substances Data)

Upstream product

• 111771-13-2 2-bromo-4-fluorobenzoyl chloride 
• 765-30-0 Cyclopropylamine 
• 394-28-5 2-Bromo-5-fluorobenzoic acid 

Relevant articles and documents

Palladium-catalyzed ring-opening of cyclopropyl benzamides: Synthesis of benzo[c]azepine-1-ones via C(sp3)-H functionalization

A variety of difficult to obtain benzo[c]azepine-1-ones are synthesized via a novel palladium-catalyzed, silver-promoted intramolecular cyclization of cyclopropyl benzamides. This biologically important class of molecules is prepared in an efficient and high-yielding manner from easily accessible starting materials. Both aryl bromides and iodides are effective substrates for the transformation. Mechanistic studies indicate that the reaction proceeds through a cyclopropyl C(sp3)-H cleavage step, followed by ring-opening, deprotonation, and reductive elimination.