101712-01-0Relevant articles and documents
Studies directed toward synthesis of the structure proposed for stereocalpin A
Huang, Yixian,Wu, Yikang
, p. 1185 - 1191 (2011)
Some synthetic efforts directed to the proposed structure of stereocalpin A are disclosed. The stereogenic centers in the aldol unit were installed using the method of Evans and the intermediates obtained through a reliable route helped to reveal that the
Biomimetic Synthesis of Lankacidin Antibiotics
Zheng, Kuan,Shen, Defeng,Hong, Ran
, p. 12939 - 12942 (2017)
We devised short syntheses of lankacidinol and lankacyclinol that feature biomimetic Mannich macrocyclization. The modular construction of the carbon framework of these compounds is amenable to rapid structural diversification for the development of antib
Leiodermatolide derivatives and their use
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Page/Page column 6; 16, (2016/08/17)
The present invention refers to leiodermatolide derivatives and the use thereof as cytotoxic agents, in particular in the form of ADC s.
Synthesis, molecular editing, and biological assessment of the potent cytotoxin leiodermatolide
Mailhol, Damien,Willwacher, Jens,Kausch-Busies, Nina,Rubitski, Elizabeth E.,Sobol, Zhanna,Schuler, Maik,Lam, My-Hanh,Musto, Sylvia,Loganzo, Frank,Maderna, Andreas,Fürstner, Alois
, p. 15719 - 15729 (2014/12/11)
It was by way of total synthesis that the issues concerning the stereostructure of leiodermatolide (1) have recently been solved; with the target now being unambiguously defined, the mission of synthesis changes as to secure a meaningful supply of this ex