1017789-26-2Relevant articles and documents
Two-directional approach for the rapid synthesis of 2,4-bis-aminoaryl pyridine derivatives
Morgentin, Remy,Barlaam, Bernard,Foote, Kevin,Hassall, Lorraine,Hawkins, Janet,Jones, Clifford D.,Le Griffon, Antoine,Peru, Aurelien,Ple, Patrick
experimental part, p. 8 - 24 (2011/10/18)
We have developed two different approaches in parallel to rapidly access 2,4-bis aminoaryl pyridine compounds from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then C-2. An alternative C-2/C-4 route uses a regioselective SNAr reaction to first substitute at C-2 then subsequently at C-4 by a palladium-mediated reaction. Both approaches have been used successfully to provide a range of 2,4-bis-aminoaryl pyridine compounds.
2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines
Zificsak, Craig A.,Theroff, Jay P.,Aimone, Lisa D.,Albom, Mark S.,Angeles, Thelma S.,Brown, Rebecca A.,Galinis, Deborah,Grobelny, Jennifer V.,Herbertz, Torsten,Husten, Jean,Kocsis, Laura S.,Losardo, Christine,Miknyoczki, Sheila J.,Murthy, Seetha,Rolon-Steele, Damaris,Underiner, Ted L.,Wells-Knecht, Kevin J.,Worrell, Candace S.,Zeigler, Kelli S.,Dorsey, Bruce D.
scheme or table, p. 660 - 663 (2011/03/18)
Elaboration of the SAR around a series of 2,4-diaminopyrimidines led to a number of c-Met inhibitors in which kinase selectivity was modulated by substituents appended on the C4-aminobenzamide ring and the nature of the C2-aminoaryl ring. Further lead opt
PYRIDINE COMPOUNDS
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Page/Page column 149, (2010/01/12)
The present invention relates to compounds that inhibit of focal adhesion kinase function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases such as cancer.
