1018069-07-2

Basic information

• Product Name: C₂₄H₂₁FN₂O₂
• CAS NO: 1018069-07-2
• Molecular Weight: 388.441
• Mol File: 1018069-07-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₁FN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₁FN₂O₂(1018069-07-2)
• EPA Substance Registry System: C₂₄H₂₁FN₂O₂(1018069-07-2)

Safety Data

• Hazardous Substances Data: 1018069-07-2(Hazardous Substances Data)

Upstream product

• 1018070-56-8 C₂₁H₁₆N₂O₂ 
• 312-68-5 3-fluoropropyl tosylate 

Relevant articles and documents

Synthesis and evaluation of stilbenylbenzoxazole and stilbenylbenzothiazole derivatives for detecting β-amyloid fibrils

This paper describes a novel series of stilbenylbenzoxazole (SBO) and stilbenylbenzothiazole (SBT) derivatives for β-amyloid specific binding probes. These 24 compounds were synthesized and evaluated by competitive binding assay against β-amyloid 1-42 (Aβ42) aggregates using [125I]TZDM. All the derivatives displayed higher binding affinities with Ki value in the subnanomolar range (0.10-0.74 nM) than Pittsburgh Compound-B (PIB) (0.77 nM). Among these derivatives, SBT-2, 5-fluoroethoxy-2-{4-[2-(4-methylaminophenyl)vinyl]phenyl}benzothiazole, showed lowest Ki value (0.10 nM). In conclusion, the preliminary results suggest that these compounds are implying a possibility as a probe for detection of Aβ fibrils in Alzheimer's disease (AD) patients.