10182-84-0

Basic information

• Product Name: DIPHENYLENEIODONIUM CHLORIDE
• Synonyms: [1,1'-BIPHENYL]-2,2'-DIYLIODONIUM CHLORIDE;DIPHENYLENEIODONIUM CHLORIDE;DIBENZIODOLIUM CHLORIDE;DPI;DPI CHLORIDE;1483-72-3 (Chloride);1483-73-4 (Bromide);2217-79-0 (Iodide)
• CAS NO: 10182-84-0
• Molecular Formula: C₁₂H₁₀I
• Molecular Weight: 314.55
• EINECS: 211-962-8
• Mol File: 10182-84-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: DIPHENYLENEIODONIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DIPHENYLENEIODONIUM CHLORIDE(10182-84-0)
• EPA Substance Registry System: DIPHENYLENEIODONIUM CHLORIDE(10182-84-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 10182-84-0(Hazardous Substances Data)

Usage

General Description

Diphenyleneiodonium chloride is a chemical compound used as a potent inhibitor of NADPH oxidase, an enzyme involved in the production of reactive oxygen species. It is often employed in research and pharmaceutical applications to study the role of NADPH oxidase in various physiological and pathological processes, including inflammation, oxidative stress, and immune responses. Additionally, diphenyleneiodonium chloride has also been investigated for its potential therapeutic properties, particularly in the treatment of diseases associated with excessive oxidative stress, such as cardiovascular diseases, neurodegenerative disorders, and certain types of cancer. Overall, this chemical compound plays a crucial role in understanding and modulating the activity of NADPH oxidase and related oxidative pathways in various scientific and medical contexts.

InChI:InChI=1/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1

Upstream product

• 932-72-9 (Dichloroiodo)benzene 
• 536-80-1 iodosylbenzene 
• 108-88-3 toluene 
• 300669-23-2 triphenyl-iodan 
• 60-29-7 diethyl ether 
• 960-71-4 triphenylborane 
• 71-43-2 benzene 
• 1122-42-5 2-iodo-p-xylene 
• 1449510-56-8 2,5-dimethoxyphenyl(phenyl)iodonium triflate 
• 144930-49-4 1-2,4-dimethylphenyl-2-phenyliodonium triflate 

Downstream Products

• 300669-23-2 triphenyl-iodan 
• 20677-03-6 di-n-propyl phenylphosphonate 
• 1754-49-0 diethyl phenylphosphonate 
• 92-52-4 biphenyl 
• 65452-72-4 4-(2-phenyl-2H-tetrazol-5-yl)pyridine 
• 18039-45-7 2,5-diphenyl-2H-tetrazole 
• 520-03-6 N-phenylphthalimide 

Related news

Different procedures of DIPHENYLENEIODONIUM CHLORIDE (cas 10182-84-0) addition affect neutrophil extracellular trap formation07/19/2019

A unique strategy, in which invading microorganisms are being caught in web-like structures composed mainly of DNA, involves a recently described phenomenon called NETosis. This process seems to be related to the production of reactive oxygen species (ROS). In our study, the influence of dipheny...detailed

Relevant articles and documents

Arylation with unsymmetrical diaryliodonium salts: A chemoselectivity study

Phenols, anilines, and malonates have been arylated under metal-free conditions with twelve aryl(phenyl)iodonium salts in a systematic chemoselectivity study. A new "anti-ortho effect" has been identified in the arylation of malonates. Several "dummy groups" have been found that give complete chemoselectivity in the transfer of the phenyl moiety, irrespective of the nucleophile. An aryl exchange in the diaryliodonium salts has been observed under certain arylation conditions. DFT calculations have been performed to investigate the reaction mechanism and to elucidate the origins of the observed selectivities. These results are expected to facilitate the design of chiral diaryliodonium salts and the development of catalytic arylation reactions that are based on these sustainable and metal-free reagents. Copyright