101820-88-6

Basic information

• Product Name: (Z)-4-benzylidene-2-methyl-4,5-dihydro-1H-imidazol-5-one
• Synonyms: (Z)-4-benzylidene-2-methyl-4,5-dihydro-1H-imidazol-5-one
• CAS NO: 101820-88-6
• Molecular Weight: 186.213
• Mol File: 101820-88-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (Z)-4-benzylidene-2-methyl-4,5-dihydro-1H-imidazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-4-benzylidene-2-methyl-4,5-dihydro-1H-imidazol-5-one(101820-88-6)
• EPA Substance Registry System: (Z)-4-benzylidene-2-methyl-4,5-dihydro-1H-imidazol-5-one(101820-88-6)

Safety Data

• Hazardous Substances Data: 101820-88-6(Hazardous Substances Data)

Upstream product

• 38243-38-8 α-N-acetylaminocinnamamide 
• 100-52-7 benzaldehyde 
• 38879-46-8 (Z)-4-benzylidene-2-methyl-5(4H)-oxazolone 
• 15813-24-8 (Z)-2-bromo-3-phenylacrylic acid 
• 124-42-5 acetamidine hydrochloride 
• 55065-02-6 N-acetamido cinnamic acid 
• 4915-81-5 2-methyl-4,5-dihydro-1H-5-imidazolone 

Downstream Products

• 258354-14-2 (Z)-2-((4-benzylidene)-2-methyl-5-oxo-4,5-dihihydro-1H-imidazol-1-yl)acetic acid 
• 102006-97-3 3-acetyl-5-benzylidene-2-styryl-3,5-dihydro-imidazol-4-one 
• 111032-07-6 5-benzylidene-2-styryl-3,5-dihydro-imidazol-4-one 

Relevant articles and documents

Photochromic DNA having fluorescent protein-inspired nucleosides

Molecular switches controlled by light stimuli can be applicable to the variety of the biological application. In this study, skeletal structures of a chromophore of fluorescent protein were applied as aglycones of newly designed photochromic nucleosides, “Fluorescent protein-inspired nuceloside: FIN”. Phosphoramidite units of the photochromic nucleosides having imidazolinone derivatives with benzylidene or 3-pyridilidene groups were successfully synthesized for FIN-containing ODNs. Thermodynamic studies of the FIN-containing ODNs revealed that photo-irradiation with specific wavelength induced stability change of the duplexes.

Simple and efficient copper-catalyzed approach to 2,4-disubstituted imidazolones

(Figure Presented) Some imidazolone derivatives are biological and pharmaceutical active molecules and the chromophores of the fluorescent proteins. In this communication, a simple and efficient approach to 4-arylidene-2-alkyl-4,5-dihydro-1H-imidazol-5-ones (2,4-disubstituted imidazolones) has been developed, and the protocol uses readily available 2-bromo-3-alkylacrylic acids and amidines as the starting materials without addition of any ligand or additive. The reactions were performed under mild conditions. Therefore, the present method will be of wide application in organic chemistry and medicinal chemistry.

Biomimetic oxidation of 2-methylimidazole derivative with a chemical model system for cytochrome P-450

A chemical model system for cytochrome P-450, consisting of tetraphenylporphyrin manganese chloride (TPPMnCl) and iodosylbenzene, efficiently oxidized 2-methylimidazole to 2-methylimidazolone. This system next applied to 4-(2-methyl-1-imidazolyl)-2,2-diph