101821-30-1Relevant articles and documents
A single-reagent-driven multistep one-pot preparation of thiazolines and 1,3-thiazines from aldoximes, nitriles, and carboxylic acids
Bhattacharyya, Shubhankar,Pathak, Uma
, p. 3553 - 3560 (2015)
N-(ω-Bromoalkyl)dichlorothiophosphoramidates have been designed as a new class of reagent for the single-reagent-driven multistep preparation of 2-substituted thiazolines and 1,3-thiazines from ald-oximes, nitriles, or carboxylic acids. A wide range of substrates both aromatic as well as aliphatic were investigated and found suitable for the developed protocol.
Transformation of anionically activated trifluoromethyl groups to heterocycles under mild aqueous conditions
Qiao, Jennifer X.,Wang, Tammy C.,Hu, Carol,Li, Jianqing,Wexler, Ruth R.,Lam, Patrick Y. S.
supporting information; experimental part, p. 1804 - 1807 (2011/06/19)
The (hetero)aromatic trifluoromethyl group is present in many biologically active molecules and is generally considered to be chemically stable. In this paper, a convenient one-step synthesis of C-C linked aryl-heterocycles or heteroaryl-heterocycles in good to excellent yields via the reaction of anionically activated trifluoromethyl groups with amino nucleophiles containing a second NH, OH, or SH nucleophile in 1 N sodium hydroxide is reported. The method has high functional group tolerability and is potentially useful in parallel synthesis.
