101828-21-1 Usage
Description
N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine, also known as Butenafine, is a synthetic benzylamine antifungal agent structurally and pharmacologically related to terbinafine. It functions as an inhibitor of squalene epoxidase, an enzyme crucial for the synthesis of sterols in fungal cell membranes. This inhibition leads to a decrease in ergosterol and an increase in squalene, causing alterations in cell membrane permeability and ultimately resulting in cell death.
Uses
Used in Dermatology:
N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine is used as an antifungal agent for the treatment of dermatological fungal infections. Its application is particularly effective against dermatophytes, yeast, and Sporothrix due to its ability to inhibit squalene epoxidase, disrupting the fungal cell membrane and causing cell death.
Used in Antifungal Medications:
N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine is used as the active ingredient in antifungal medications, such as Lotrimin (Schering) and Mentax (Mylan Bertek), for treating various skin infections caused by fungi. Its effectiveness in inhibiting squalene epoxidase makes it a valuable component in these medications, providing relief and treatment for patients suffering from fungal infections.
Check Digit Verification of cas no
The CAS Registry Mumber 101828-21-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,8,2 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 101828-21:
(8*1)+(7*0)+(6*1)+(5*8)+(4*2)+(3*8)+(2*2)+(1*1)=91
91 % 10 = 1
So 101828-21-1 is a valid CAS Registry Number.
InChI:InChI=1/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3
