1018434-46-2

Basic information

• Product Name: (E)-2,2-difluoro-1-methylethylidene((1R)-2-trimethylsilyloxy-1-phenylethyl)amine
• CAS NO: 1018434-46-2
• Molecular Weight: 285.409
• Mol File: 1018434-46-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2,2-difluoro-1-methylethylidene((1R)-2-trimethylsilyloxy-1-phenylethyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2,2-difluoro-1-methylethylidene((1R)-2-trimethylsilyloxy-1-phenylethyl)amine(1018434-46-2)
• EPA Substance Registry System: (E)-2,2-difluoro-1-methylethylidene((1R)-2-trimethylsilyloxy-1-phenylethyl)amine(1018434-46-2)

Safety Data

• Hazardous Substances Data: 1018434-46-2(Hazardous Substances Data)

Upstream product

• 56613-80-0 D-2-phenylglycinol 
• 1018435-02-3 (1,1-difluoroprop-1-en-2-yloxy)trimethylsilane 

Downstream Products

• 1018434-49-5 (2S,4R)-2-difluoromethyl-2-methyl-4-phenyl-1,3-oxazolidine 
• 1018434-47-3 (E)-2,2-difluoro-1-methylethylidene((1R)-2-hydroxy-1-phenylethyl)amine 
• 1018434-86-0 (R)-2-difluoromethyl-2-((1R)-1-phenyl-2-hydroxyethylamino)propionitrile 
• 1018434-83-7 (S)-2-difluoromethyl-2-((1R)-1-phenyl-2-hydroxyethylamino)propionitrile 
• 1018434-51-9 (2S,4R)-N-benzoyl-2-difluoromethyl-2-methyl-4-phenyl-1,3-oxazolidine 
• 1018434-53-1 (2R,4R)-N-benzoyl-2-difluoromethyl-2-methyl-4-phenyl-1,3-oxazolidine 

Relevant articles and documents

Umpolung reactivity of difluoroenol silyl ethers with amines and amino alcohols. Application to the synthesis of enantiopure α-difluoromethyl amines and amino acids

(Chemical Equation Presented) Difluoroenol silyl ethers, produced in situ from acylsilanes and CF3TMS, react as electrophiles with amines to give difluoroimines, via the corresponding hemiaminal adduct, as evidenced by 19F NMR spectr