1018553-10-0Relevant articles and documents
Synthesis of iminonitriles by oxone/tbab-mediated one-pot oxidative three-component strecker reaction
Gualtierotti, Jean-Baptiste,Schumacher, Xavier,Wang, Qian,Zhu, Jieping
, p. 1380 - 1386 (2013)
Oxidative three-component reaction of aldehydes, amines, and TMSCN in a biphasic solvent system (toluene/H2O) containing Oxone, tetra-n-butylammonium bromide (TBAB) and sodium bicarbonate afforded α-iminonitriles in good to excellent yields. This oxidative Strecker reaction was applicable to a wide range of aldehydes and amines, aromatic or aliphatic, of different electronic and steric properties. Substituted 1-aza-2-cyano-1,3-dienes were also accessible using α,β-unsaturated aldehydes as inputs.