1018785-60-8Relevant articles and documents
5-Bis-(2,6-difluoro-benzylidene) Cyclopentanone Acts as a Selective 11β-Hydroxysteroid Dehydrogenase one Inhibitor to Treat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice
Guan, Hongguo,Wang, Yiyan,Li, Huitao,Zhu, Qiqi,Li, Xiaoheng,Liang, Guang,Ge, Ren-Shan
, (2021/05/04)
Background: 11β-Hydroxysteroid dehydrogenase one is responsible for activating inert glucocorticoid cortisone into biologically active cortisol in humans and may be a novel target for the treatment of nonalcoholic fatty liver disease. Methods: A series of
Synthesis and anti-inflammatory evaluation of novel mono-carbonyl analogues of curcumin in LPS-stimulated RAW 264.7 macrophages
Zhao, Chengguang,Cai, Yuepiao,He, Xuzhi,Li, Jianling,Zhang, Li,Wu, Jianzhang,Zhao, Yunjie,Yang, Shulin,Li, Xiaokun,Li, Wulan,Liang, Guang
experimental part, p. 5773 - 5780 (2011/02/22)
Curcumin is a multifunctional natural product with regulatory effects on inflammation. However, a major limitation for the application of curcumin is its poor bioavailability. We previously demonstrated that the mono-carbonyl analogues of curcumin possess
Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin
Liang, Guang,Li, Xiaokun,Chen, Li,Yang, Shulin,Wu, Xudong,Studer, Elaine,Gurley, Emily,Hylemon, Phillip B.,Ye, Faqing,Li, Yueru,Zhou, Huiping
, p. 1525 - 1529 (2008/09/19)
Curcumin has been extensively studied for its anti-inflammatory activities. However, its potential beneficial effects on various disease preventions and treatments are limited by its unstable structure. The β-diketone moiety renders curcumin to be rapidly metabolized by aldo-keto reductase in liver. In the present study, a series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an enhanced ability to inhibit lipopolysaccharide (LPS)-induced TNF-α and IL-6 synthesis in macrophages.
