101885-60-3Relevant articles and documents
Lipidic Peptides, XIV. Conversion of Racemic Lipidic Amino Acids into Sphingosine and Ceramide Analogues and 1,2-Diamines
Kokotos, George,Constantinou-Kokotou, Violetta,Fernandez, Esther del Olmo,Toth, Istvan,Gibbons, William A.
, p. 961 - 964 (2007/10/02)
N-Protected racemic lipidic amino acids 1a-h were converted directly into ceramide analogues 2a-h by chemoselective reduction of their corresponding mixed anhydrides with sodium tetrahydroborate.Conversion of the compounds 1a, b into the corresponding acyl azides, followed by catalytic hydrogenation gave the N-monoprotected lipidic 1,2-diamines 5a, b.The sphingosine analogues 7a-c and the free 1,2-diamines 6a, b were synthesized by deprotection of the compounds 2a-c and 5a, b, respectively.Key Words: Amino acids / Spingosines / Ceramides / Amino alcohols / 1,2-Diamines