1018858-59-7

Basic information

• Product Name: 7-(3-nitrophenyl)hept-6-yn-2-one
• Synonyms: 7-(3-nitrophenyl)hept-6-yn-2-one
• CAS NO: 1018858-59-7
• Molecular Weight: 231.251
• Mol File: 1018858-59-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(3-nitrophenyl)hept-6-yn-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(3-nitrophenyl)hept-6-yn-2-one(1018858-59-7)
• EPA Substance Registry System: 7-(3-nitrophenyl)hept-6-yn-2-one(1018858-59-7)

Safety Data

• Hazardous Substances Data: 1018858-59-7(Hazardous Substances Data)

Upstream product

• 645-00-1 m-iodonitrobenzene 
• 928-39-2 hept-6-yn-2-one 

Relevant articles and documents

N-Phenyl-N′-(2-chloroethyl)ureas (CEUs) as potential antineoplastic agents. Part 3: Role of carbonyl groups in the covalent binding to the colchicine-binding site

In the course of the development of N-phenyl-N′-(2-chloroethyl)ureas (CEUs) as potential antineoplastic agents, we investigated the effect of carbonylated substituting chains of the aromatic ring of CEU on their covalent binding to the colchicine-binding site (C-BS). In this study, we found that CEU, 5e, 5f, 8e, and 8f substituted by either a methyl ester or a methyl ketyl group at the ω-position exhibited a significant antiproliferative activity on HT-29, M21, and MCF-7 tumor cells. SDS-PAGE assays and cell cycle analysis confirmed that 5e, 5f, 8e, and 8f covalently bind to the C-BS and arrest the cell division in G2/M phase. Surprisingly, the presence of ω-carboxyl, ω-ethyl esters or ω-amides decreased significantly both the antiproliferative activity and the specificity toward β-tubulin.