1019-52-9

Basic information

• Product Name: 3,5-DINITRO-4-HYDROXYBENZOIC ACID
• Synonyms: 3,5-DINITRO-4-HYDROXYBENZOIC ACID;4-HYDROXY-3,5-DINITROBENZOIC ACID;AKOS BB-9288;4-HYDROXY-3 5-DINITROBENZOIC ACID 95%;3,5-Dinitro-4-hydroxybenzoic acid, 98+%;4-Carboxy-2,5-dinitrophenol;3,5-Dinitro-4-Hydroxy Benzoic Acid (4-Hydroxy-3,5-Dinitrobenzoic Acid);3,5-Dinitro-4-hydroxybenzonic Acid
• CAS NO: 1019-52-9
• Molecular Formula: C₇H₄N₂O₇
• Molecular Weight: 228.12
• EINECS: 213-814-8
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 1019-52-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 245 °C (dec.)(lit.)
• Boiling Point: 369.91°C (rough estimate)
• Flash Point: 155.7°C
• Appearance: /
• Density: 1.7914 (rough estimate)
• Vapor Pressure: 1.76E-05mmHg at 25°C
• Refractive Index: 1.5300 (estimate)
• PKA: 2.02±0.10(Predicted)
• CAS DataBase Reference: 3,5-DINITRO-4-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DINITRO-4-HYDROXYBENZOIC ACID(1019-52-9)
• EPA Substance Registry System: 3,5-DINITRO-4-HYDROXYBENZOIC ACID(1019-52-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 1019-52-9(Hazardous Substances Data)

Usage

Uses

3,5-Dinitro-4-hydroxybenzoic Acid is used in preparation of benzamide derivatives as corticotropin releasing factor receptor antagonists.

InChI:InChI=1/C7H4N2O7/c10-6-4(8(13)14)1-3(7(11)12)2-5(6)9(15)16/h1-2,10H,(H,11,12)/p-2

Upstream product

• 3681-93-4 vitexin 
• 577-52-6 4-bromo-3,5-dinitrobenzoic acid 
• 7221-27-4 4-amino-3,5-dinitrobenzoic acid 
• 393-77-1 α,α,α-Trifluoro-2,6-dinitro-p-cresol 
• 85365-92-0 3,5-dinitro-4-methoxybenzoic acid 
• 861298-98-8 4-methoxy-3,5-dinitro-benzoic acid amide 
• 33927-05-8 methyl 3,5-dinitro-4-hydroxybenzoate 
• 529-53-3 scutellarein 
• 163205-74-1 2-hydroxyl-5-carboxylbenzenesulfonic acid 
• 860725-17-3 4-bromo-3,5-dinitro-benzaldehyde 
• 2365-71-1 3,5-dinitro-4-fluorobenzoic acid 
• 90325-30-7 3,4,5-trinitro-benzoic acid 
• 861792-53-2 4-methoxycarbonylmethoxy-3,5-dinitro-benzoic acid methyl ester 
• 99-96-7 4-hydroxy-benzoic acid 

Downstream Products

• 33927-05-8 methyl 3,5-dinitro-4-hydroxybenzoate 
• 34384-49-1 4-hydroxy-3,5-dinitro-benzoic acid propyl ester 
• 135252-15-2 3,5-diamino-4-hydroxy-benzoic acid 
• 54321-79-8 4-amino-3,5-dinitrobenzamide 
• 267014-44-8 3-amino-4-hydroxy-5-nitro-benzoic acid 
• 1071553-39-3 3-amino-4-hydroxy-5-nitro-benzoic acid methyl ester 
• 357332-77-5 4-hydroxy-3,5-dinitrobenzoyl chloride 
• 1443011-81-1 C₁₈H₁₇N₃O₂ 
• 1443011-82-2 C₁₁H₁₅N₃O₂ 
• 1443011-75-3 3,5-bis[(furan-2-ylmethyl)amino]-4-hydroxy-N-(naphthalen-2-ylmethyl)benzamide 
• 1443011-76-4 {4-hydroxy-3,5-bis[(thiazol-2-ylmethyl)amino]phenyl}(pyrrolidin-1-yl)methanone 
• 1443011-78-6 4-hydroxy-N-(naphthalen-2-ylmethyl)-3,5-dinitrobenzamide 
• 1443011-79-7 (4-hydroxy-3,5-dinitrophenyl)(pyrrolidin-1-yl)methanone 

Relevant articles and documents

Trichloroisocyanuric Acid/NaNO2/wet SiO2 as an Efficient System for the Selective Dinitration of Phenols under Solvent-free Conditions

Dinitrophenols can be obtained via direct nitration of phenols with trichloroisocyanuric acid, NaNO2 and wet SiO2 at room temperature under solvent-free conditions with moderate to high yields.

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PEG-N2O4: An efficient nitrating agent for the selective mono- and dinitration of phenols under mild conditions

N2O4 was easily impregnated on polyethyleneglycol to give a stable reagent. The polyethyleneglycol-N2O4 (PEG-N2O4) system was used as an effective nitrating agent for the nitration of phenols. Mono- and dinitrophenols can be obtained via direct nitration of phenols in the presence of PEG-N2O4 at room temperature in moderate to high yields. Copyright Taylor & Francis Group, LLC.

The Effects of Single- and Twin-Tailed Ionic Surfactants on the Hydroxy- dehalogenation of Charged Substrates

Reactions of OH- with 4-chloro-3,5-dinitrobenzoic and 2-chloro-3,5-dinitrobenzoic acids have been examined in solutions of cetyltrimethylammonium chloride, bromide and hydroxide, bis(dodecyl)dimethylammonium chloride, and bis(tetradecyl)dimethylammonium chloride.Rate effects were analysed quantitatively in terms of the distribution of reactants between water and the colloidal particles.It has been found that twin-tailed ionic surfactants better distinguish between favourable and unfavourable orientations of substrate molecules within micellar aggregates than do single-tailed ionic surfactants.