10190-93-9 Usage
Description
17BETA-HYDROXY-4-ANDROSTEN-3-ONE 3-[O-CARBOXYMETHYL]OXIME, also known as Testosterone 3-(O-carboxymethyl)oxime, is a chemical compound derived from testosterone. It is characterized by the presence of a carboxymethyl oxime group attached to the 3-oxo position, which allows for the conjugation with enzymes or other molecules for various applications.
Uses
Used in Diagnostic Applications:
17BETA-HYDROXY-4-ANDROSTEN-3-ONE 3-[O-CARBOXYMETHYL]OXIME is used as a precursor for the preparation of horseradish peroxidase (HRP)-labeled testosterone. This conjugated form is utilized in enzyme immunoassays to measure plasma testosterone concentration, providing a reliable and sensitive method for assessing testosterone levels in clinical and research settings.
Biochem/physiol Actions
Androgens direct the development of male reproductive system and secondary sexual characteristics. Testosterone is an androgen that is secreted by the testis. This hormone is converted to dihydrotestosterone (DHT) by 5α reductase in the target tissues. Both DHT and testosterone require androgen receptor, a ligand-dependent nuclear transcription factor to mediate their biological functions.
Check Digit Verification of cas no
The CAS Registry Mumber 10190-93-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,9 and 0 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 10190-93:
(7*1)+(6*0)+(5*1)+(4*9)+(3*0)+(2*9)+(1*3)=69
69 % 10 = 9
So 10190-93-9 is a valid CAS Registry Number.
10190-93-9Relevant articles and documents
Forest et al.
, p. 815,816 (1976)
A novel 99mTc-labeled testosterone derivative as a potential agent for targeting androgen receptors
Das, Tapas,Banerjee, Sharmila,Samuel, Grace,Bapat, Ketaki,Subramanian, Suresh,Pillai, Maroor R.A.,Venkatesh, Meera
, p. 5788 - 5792 (2006)
With an insight that ligands possessing a N2S2 tetradentate array of donor atoms serve as ideal bifunctional chelating agents (BFCA) in the radiolabeling of target-specific agents, 5-hydroxy-3,7-diazanonan-1,9-dithiol (DAHPES) with a derivatizable substituent in the form of a hydroxyl group in the backbone was synthesized. The preparation of a steroid conjugate via coupling of this BFCA with testosterone-3-(O-carboxymethyl) oxime and the subsequent radiolabeling of the conjugate under optimized conditions with 99mTc, the ideal diagnostic radionuclide in nuclear medicine procedures, are reported. The immunoreactivity of the radiolabeled conjugate was demonstrated in a study using anti-testosterone antibodies, wherein the radiolabeled conjugate exhibited significant binding with antiserum to testosterone. Cell-uptake studies in DU145 prostate carcinoma cell line bearing androgen receptors (ARs) and comparison with AR non-bearing breast carcinoma cell line revealed the specific binding of the steroidal moiety with the testosterone receptor.