1019652-26-6Relevant articles and documents
Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists
Pasternak, Alexander,Goble, Stephen D.,Doss, George A.,Tsou, Nancy N.,Butora, Gabor,Vicario, Pasquale P.,Ayala, Julia Marie,Struthers, Mary,DeMartino, Julie A.,Mills, Sander G.,Yang, Lihu
, p. 1374 - 1377 (2008/09/19)
In an effort to shed light on the active binding conformation of our 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists, we prepared several conformationally constrained analogs resulting from backbone cyclization. Evaluation of CCR2 binding affini
