1019683-19-2Relevant articles and documents
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)
Schaefer, Stefan,Saunders, Laura,Eliseeva, Elena,Velena, Alfredo,Jung, Mira,Schwienhorst, Andreas,Strasser, Anja,Dickmanns, Achim,Ficner, Ralf,Schlimme, Sonja,Sippl, Wolfgang,Verdin, Eric,Jung, Manfred
, p. 2011 - 2033 (2008/09/21)
We synthesized biarylalanine-containing hydroxamic acids and tested them on immunoprecipitated HDAC1 and HDAC6 and show a subtype selectivity for HDAC6 that was confirmed in cells by Western blot (tubulin vs histones). We obtained an X-ray structure with