1019775-41-7Relevant articles and documents
Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors
Wu, Zhicai,Hartnett, John C.,Neilson, Lou Anne,Robinson, Ronald G.,Fu, Sheng,Barnett, Stanley F.,Defeo-Jones, Deborah,Jones, Raymond E.,Kral, Astrid M.,Huber, Hans E.,Hartman, George D.,Bilodeau, Mark T.
, p. 1274 - 1279 (2008/09/19)
This communication reports a new synthetic route of pyridopyrimidines to facilitate their structural optimization in a library fashion and describes the development of pyridopyrimidines that have excellent enzymatic and cell potency against Akt1 and Akt2.
