102-98-7 Usage
Description
Phenylmercuric borate is a chemical compound that is known for its colorless, shiny flake form or as a white or slightly yellow, odorless, crystalline powder. It is a mercury-based compound that has unique chemical properties and potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
Phenylmercuric borate is used as a preservative for its antimicrobial properties. It helps in preventing the growth of bacteria, fungi, and other microorganisms in pharmaceutical products, ensuring their safety and efficacy.
Used in Cosmetics Industry:
In the cosmetics industry, Phenylmercuric borate is used as a preservative to maintain the freshness and quality of cosmetic products. Its ability to inhibit microbial growth helps in preventing spoilage and contamination, thus extending the shelf life of cosmetics.
Used in Research and Development:
Phenylmercuric borate is also utilized in research and development for its unique chemical properties. It can be used in various laboratory experiments and studies to understand its interactions with other compounds and its potential applications in different fields.
Used in Analytical Chemistry:
Phenylmercuric borate is employed as a reagent in analytical chemistry for the detection and analysis of certain compounds. Its specific chemical properties make it a valuable tool in identifying and quantifying target substances in various samples.
Used in Pesticide Industry:
In the pesticide industry, Phenylmercuric borate is used as an additive to enhance the effectiveness of certain pesticides. Its antimicrobial properties help in controlling the growth of harmful microorganisms that can affect the performance of the pesticides.
Used in Wood Preservation:
Phenylmercuric borate is used in the wood preservation industry as a fungicide and bactericide. It helps in protecting wood from decay and damage caused by fungi and bacteria, thus extending its lifespan and maintaining its structural integrity.
Production Methods
Phenylmercuric borate may be prepared by heating mercuric borate
with benzene or by evaporating to dryness, under vacuum, an
alcoholic solution containing equimolar proportions of phenylmercuric
hydroxide and boric acid.
Pharmaceutical Applications
Phenylmercuric borate is used as an alternative antimicrobial
preservative to phenylmercuric acetate or phenylmercuric nitrate. It
is more soluble than phenylmercuric nitrate and has also been
reported to be less irritant than either phenylmercuric acetate or
phenylmercuric nitrate.
Safety
Phenylmercuric borate is mainly used as an antimicrobial preservative
in topical pharmaceutical formulations. A number of
adverse reactions to mercury-containing preservatives have been
reported; see Phenylmercuric Nitrate.
Although phenylmercuric borate is an irritant, it has been
reported to be less so than either phenylmercuric acetate or phenylmercuric nitrate.(1) There is, however, some cross-sensitization
potential with other mercurial preservatives.
Systemic absorption has been reported following regular use of a
hand disinfectant soap containing 0.04% phenylmercuric borate,
resulting in an increase in the estimated total daily body load of
mercury from 30–100 mg per 24 hours.
storage
As for other phenylmercuric salts; see Phenylmercuric Nitrate.
Solutions may be sterilized by autoclaving.
Phenylmercuric borate should be stored in a well-closed
container, protected from light, in a cool, dry place.
Incompatibilities
Incompatible with: halides; anionic emulsifying agents and
suspending agents; tragacanth; starch; talc; sodium metabisulfite;
sodium thiosulfate; disodium edetate; silicates; aluminum and other
metals; amino acids; ammonia and ammonium salts; sulfur
compounds; rubber; and some plastics.
Phenylmercuric acetate is reported to be incompatible with
cefuroxime and ceftazidime.
Regulatory Status
Included in nonparenteral medicines licensed in Europe. Included in
the Canadian List of Acceptable Non-medicinal Ingredients
(ophthalmic, nasal and otic preparations up to 0.004%; there
must be no other suitable alternative preservative).
In Europe, use is limited to eye makeup and eye makeup remover
at not more than 0.007% mercury alone or in combination with
other permitted mercurial substances.In France, a maximum
concentration of up to 0.01% is permitted for use in pharmaceutical
formulations. Prohibited from use in cosmetic products in Canada.
Prohibited in antimicrobial diaper rash drug products in the USA.
Limited use in Japan (see Phenylmercuric Nitrate).
Check Digit Verification of cas no
The CAS Registry Mumber 102-98-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 2 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 102-98:
(5*1)+(4*0)+(3*2)+(2*9)+(1*8)=37
37 % 10 = 7
So 102-98-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H5.BH2O3.Hg/c1-2-4-6-5-3-1;2-1(3)4;/h1-5H;2-3H;/q;-1;+1/rC6H5Hg.BH2O3/c7-6-4-2-1-3-5-6;2-1(3)4/h1-5H;2-3H/q+1;-1
