1020086-26-3

Basic information

• Product Name: 4-[4-({3-[(1-methyl-4-pyridiniumyl)amino]benzoyl}amino)anilino]-6-nitroquinolinium dichloride
• Synonyms: 4-[4-({3-[(1-methyl-4-pyridiniumyl)amino]benzoyl}amino)anilino]-6-nitroquinolinium dichloride
• CAS NO: 1020086-26-3
• Molecular Weight: 563.443
• Mol File: 1020086-26-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[4-({3-[(1-methyl-4-pyridiniumyl)amino]benzoyl}amino)anilino]-6-nitroquinolinium dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-({3-[(1-methyl-4-pyridiniumyl)amino]benzoyl}amino)anilino]-6-nitroquinolinium dichloride(1020086-26-3)
• EPA Substance Registry System: 4-[4-({3-[(1-methyl-4-pyridiniumyl)amino]benzoyl}amino)anilino]-6-nitroquinolinium dichloride(1020086-26-3)

Safety Data

• Hazardous Substances Data: 1020086-26-3(Hazardous Substances Data)

Upstream product

• 13675-94-0 4-chloro-6-nitroquinoline 
• 1020087-00-6 4-{3-[(4-aminoanilino)carbonyl]anilino}-1-methylpyridinium chloride 

Downstream Products

• 1020086-29-6 6-amino-4-[4-({3-[(1-methyl-4-pyridiniumyl)amino]benzoyl}amino)anilino]quinolinium dichloride 

Relevant articles and documents

Structure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1

A series of 4-anilinoquinoline derivatives related to the known inhibitor SGI-1027, containing side chains of varying pKa, were prepared by acid-catalysed coupling of the pre-formed side chains with 4-chloroquinolines. The compounds were evaluated for their ability to reduce the level of DNMT1 protein in HCT116 human colon carcinoma cells by Western blotting. With a very strongly basic N-methylpyridinium side chain, only NHCO-linked compounds were effective, whereas less strongly basic ((diaminomethylene)hydrazono)ethyl or 3-methylpyrimidine-2,4-diamine side chains allowed both NHCO- and CONH-linked compounds to show activity. In contrast, the pKa of the quinoline unit had little apparent influence on activity.