1020107-07-6Relevant articles and documents
Organocatalytic highly enantioselective tandem Michael-Knoevenagel reaction for the synthesis of substituted thiochromanes
Dodda, Rajasekhar,Mandal, Tanmay,Zhao, Cong-Gui
, p. 1899 - 1902 (2008/09/19)
Enantioenriched tetrasubstituted thiochromanes have been synthesized using a tandem Michael addition-Knoevenagel reaction between 2-mercaptobenzaldehydes and benzylidenemalonates with a 9-epi-aminoquinine thiourea derivative as the catalyst. Steric and electron effects were found to affect profoundly the enantioselectivity and diastereoselectivity of the reaction.