1020280-96-9Relevant articles and documents
RETINOID PRODRUG COMPOUND
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A compound represented by the following general formula (I) : [R1 to R5 represent hydrogen atom, an alkyl group, or a trialkylsilyl group, X represents -NH-CO-, -CO-NH-, -N(COR6)-CO-, -CO-N(COR7)- (R6 and R7 represent a lower alkoxy group, or a carboxy-substituted phenyl group) etc.; and Z represents -Y-CH(R12)-COOH, -CHO, -CH-CH-COOH, or -COOR13 (Y represents a single bond, -CH2-, -CH(OH)-, -CO-, -CO-NH-, or -CO-NH-CH2-CO-NH-, R12 represents hydrogen atom or a lower alkyl group, and R13 represents hydrogen atom, -CH(R14)-COOH (R14 represents hydrogen atom, a lower alkyl group, or hydroxy group), -[CH2CH2-O]n-CH2-CH2-OH, CH2-O-[CH2CH2O]m-CH2-OH, or -[CH(CH3)-CO-O]p-CH(CH3)-COOH (m, n and p represent an integer of 1 to 100))], a salt thereof or an ester thereof, which has a property of being converted into a retinoid after absorption in vivo.