1020412-97-8

Basic information

• Product Name: Tie-2 Inhibitor 7
• Synonyms: Tie-2 Inhibitor 7
• CAS NO: 1020412-97-8
• Molecular Formula: C31H35N3O5
• Molecular Weight: 529.6267
• Mol File: 1020412-97-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Tie-2 Inhibitor 7(CAS DataBase Reference)
• NIST Chemistry Reference: Tie-2 Inhibitor 7(1020412-97-8)
• EPA Substance Registry System: Tie-2 Inhibitor 7(1020412-97-8)

Safety Data

• Hazardous Substances Data: 1020412-97-8(Hazardous Substances Data)

Usage

Description

Tie-2 Inhibitor 7 is a compound that blocks Tie2 kinase activity with a Ki value of 1.3 μM. It effectively inhibits angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This inhibitory action allows it to prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.

Uses

Used in Pharmaceutical Industry:
Tie-2 Inhibitor 7 is used as a therapeutic agent for targeting angiogenesis, a process critical for the growth and metastasis of various tumors. Its ability to inhibit Tie2 kinase activity and downstream signaling pathways makes it a promising candidate for the development of anti-cancer drugs.
Used in Ophthalmology:
Tie-2 Inhibitor 7 is used as a treatment for ocular disorders characterized by abnormal blood vessel growth, such as age-related macular degeneration and diabetic retinopathy. Its capacity to prevent endothelial cell tube formation and aberrant vessel growth can help manage these conditions and preserve vision.
Used in Research Applications:
Tie-2 Inhibitor 7 serves as a valuable research tool for studying the role of Tie2 kinase in angiogenesis and vascular development. It can be employed in in vitro and in vivo experiments to investigate the molecular mechanisms underlying Tie2-mediated signaling and its implications in various pathological conditions.