102042-09-1 Usage
Description
21-Hydroxyoligomycin A is a rare member of the oligomycin class, a group of macrolide antibiotics, which was isolated as a co-metabolite of nemadectin. It is characterized by the presence of a hydroxyl group at the 21st position, which distinguishes it from other members of the oligomycin family. Although there is limited literature available on this metabolite, it has shown promising potential in various applications.
Uses
Used in Pharmaceutical Industry:
21-Hydroxyoligomycin A is used as an anticancer agent for its selective action against mammalian tumor cell lines. It exhibits weak antifungal and nematocidal activity, making it a more targeted and potentially safer option for cancer treatment compared to other members of the oligomycin class.
Used in Research and Development:
Due to its rarity and unique properties, 21-hydroxyoligomycin A is used in research and development for further exploration of its potential applications and mechanisms of action. This includes studying its interactions with various biological targets and evaluating its efficacy in combination with other therapeutic agents.
Biological Activity
21-hydroxy oligomycin a is an antibiotic which was first isolated from s. cyaneogriseus ssp.noncyanogenus [1]. 21-hydroxy oligomycin a functions as μm inhibitor of the multidrug efflux pump p-gp, and low nm inhibitors of k-ras pm localization [1].cancer cell viability screening confirmed that 21-hydroxy oligomycin a was cytotoxic to human colorectal carcinoma cells (ic50 > 3 μm), and was inhibitor of the abc transporter efflux pump p-glyco-protein (p-gp). significantly, 21-hydroxy oligomycin a was exceptionally potent inhibitor of k-ras pm localisation with emax of 0.67–0.75 and an ic50 of 1.5–14 nm [1]. 21-hydroxy oligomycin a was inhibitor of k-ras pm localisation in mdck cell with an ic50 of 4.82 ± 0.70 nm. 21-hydroxy oligomycin a was moderately cytotoxic towards both sw620 and sw620 ad300 cells with the ic50 of 14.4 ± 0.6 and 11.8 ± 3.1 μm, respectively. in the flow cytometry assay, 21-hydroxy oligomycin a (20 μm) increased intracellular calcein fluorescence significantly when compared with the negative control [1].
references
[1] salim a a, tan l, huang x c, et al. oligomycins as inhibitors of k-ras plasma membrane localisation[j]. organic & biomolecular chemistry, 2016, 14(2): 711-715.
Check Digit Verification of cas no
The CAS Registry Mumber 102042-09-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,0,4 and 2 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 102042-09:
(8*1)+(7*0)+(6*2)+(5*0)+(4*4)+(3*2)+(2*0)+(1*9)=51
51 % 10 = 1
So 102042-09-1 is a valid CAS Registry Number.
InChI:InChI=1/C45H74O12/c1-12-33-17-15-13-14-16-27(4)43(10,53)44(11,54)42(52)31(8)41(51)30(7)40(50)29(6)39(49)26(3)18-19-38(48)55-37-24-34(23-35(33)47)56-45(32(37)9)21-20-25(2)36(57-45)22-28(5)46/h13-15,17-19,25-37,39,41,46-47,49,51,53-54H,12,16,20-24H2,1-11H3/b14-13-,17-15+,19-18+/t25-,26+,27+,28+,29+,30-,31-,32-,33-,34?,35?,36-,37?,39+,41+,43-,44-,45?/m0/s1
