102043-14-1Relevant articles and documents
Thioamide derivative and preparation method thereof
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Paragraph 0175-0177, (2018/11/04)
The invention discloses a thioamide derivative. The structural formula of the thioamide derivative is represented by the formula (I) or the formula (II). The invention also provides a preparation method of the thioamide derivative. According to the preparation method, alkali metal salts are taken as the alkalis, amines are directly coupled with alkenes and sulfur, and by selecting the alkali, twodifferent thioamide derivatives represented by the formula (I) and the formula (II) can be prepared from same raw materials. The provided preparation method has the advantages that the raw materials are cheap and easily available, the synthesis method is simple, and the cost is largely reduced. The provided thioamide derivatives can be used in fields such as bioactive molecules, drug synthesis, and the like, and has a wide application range.
Synthesis and evaluation of18F-labeled 2-phenylbenzothiazoles as positron emission tomography imaging agents for amyloid plaques in alzheimer's disease
Serdons, Kim,Terwinghe, Christelle,Vermaelen, Peter,Van Laere, Koen,Kung, Hank,Mortelmans, Luc,Bormans, Guy,Verbruggen, Alfons
experimental part, p. 1428 - 1437 (2009/12/26)
Imaging agents targeting amyloid β(Aβ) may be useful for early diagnosis and follow-up of treatment of patients with Alzheimer's disease (AD). Three of five tested 2-(4′-fluorophenyl)-1,3-benzothiazoles displayed high binding affinities for Aβ plaques in
