1021007-50-0Relevant articles and documents
Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides
Sasiambarrena, Leandro D.,Barri, Ivan A.,Fraga, Guido G.,Bravo, Rodolfo D.,Ponzinibbio, Agustín
supporting information, p. 264 - 267 (2019/01/04)
A facile and efficient method was developed for the synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-ones from 2-chloro-N-(2-nitrobenzyl)acetamides through a reductive cyclization using iron-ammonium chloride in ethanol–water in good yields. This method provides a simple approach to these benzodiazepine-3-ones which are of high value in the field of medicinal chemistry research.