1021267-09-3

Basic information

• Product Name: 2'-hydroxy-4'-methoxyacetophenone imine
• Synonyms: 2'-hydroxy-4'-methoxyacetophenone imine
• CAS NO: 1021267-09-3
• Molecular Weight: 165.192
• Mol File: 1021267-09-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2'-hydroxy-4'-methoxyacetophenone imine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-hydroxy-4'-methoxyacetophenone imine(1021267-09-3)
• EPA Substance Registry System: 2'-hydroxy-4'-methoxyacetophenone imine(1021267-09-3)

Safety Data

• Hazardous Substances Data: 1021267-09-3(Hazardous Substances Data)

Upstream product

• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 

Downstream Products

• 1033425-29-4 (E)-1,1,1-trichloro-3-nitro-N-[1-(2-hydroxy-4-methoxyphenyl)ethylidene]propan-2-amine 
• 1228553-89-6 (S)-2-(1-aminoethyl)-5-methoxyphenol 
• 1021267-65-1 2-(1-aminoethyl)-5-methoxyphenol 
• 23999-64-6 6-methoxy-2-methyl-benzoxazole 
• 73344-39-5 6-methoxy-3-methyl-1,2-benzisoxazole 

Relevant articles and documents

A kind of benzo [d] different wicked zuozuo apperception compound and use thereof

The invention relates to the technical field of chemical medicine, and particularly discloses a benzo[d]isoxazole compound shown as a general formula (A) and application thereof. The compound can effectively inhibit bromodomain of BET family proteins so as to block interaction between the BET family proteins and chromatin histone to adjust genetic transcription, cause changing of a downstream signal path and exert important influence on various diseases, so that the compound and a combination thereof can be used for preparing medicine for treating or preventing diseases like tumorigenesis, inflammation, viral infection, cell proliferation disorder, autoimmune diseases and septicemia.

A divergent and selective synthesis of isomeric benzoxazoles from a single N-Cl imine

A divergent and regioselective synthesis of either 3-substituted benzisoxazoles or 2-substituted benzoxazoles from readily accessible ortho-hydroxyaryl N-H ketimines is described. The reaction proceeds in two distinct pathways through a common N-Cl imine intermediate: (a) N-O bond formation to form benzisoxazole under anhydrous conditions and (b) NaOCl mediated Beckmann-type rearrangement to form benzoxazole, respectively. The reaction path also depends on the electronic nature of the aromatic ring, with the electron-rich aromatic rings favoring the rearrangement and the electron-deficient rings favoring the N-O bond formation. A Beckmann-type rearrangement mechanism via net [1,2]-aryl migration for the formation of 2-substituted benzoxazole is proposed.

A simple and convenient synthesis of 4-methyl-3-nitro-2-trihalomethyl-2H-chromenes from N-unsubstituted imines of 2-hydroxyacetophenones and trichloro(trifluoro)ethylidene nitromethanes

The reaction of N-unsubstituted imines of 2-hydroxyacetophenones with trichloro(trifluoro)ethylidene nitromethanes in the presence of DABCO proceeds via tandem oxa-Michael/aza-Henry additions (in dichloromethane) or aza-Michael addition (in benzene) to give 4-methyl-3-nitro-2-trichloro(trifluoro)methyl-2H-chromenes or 1,1,1-trichloro(trifluoro)-3-nitro-N-[1-(2-hydroxyaryl)ethylidene]propan-2-amines, respectively.