1021327-13-8Relevant articles and documents
Highly enantioselective palladium-catalyzed alkylation of acyclic amides
Zhang, Kai,Peng, Qian,Hou, Xue-Long,Wu, Yun-Dong
supporting information; scheme or table, p. 1741 - 1744 (2009/02/06)
(Chemical Equation Presented) Even acyclic amides are suitable nucleophile subtrates for asymmetric allylic alkylations. The allylation products are formed in high yields in the presence of a palladium catalyst with a 1,1′-P,N ferrocene ligand (see scheme; R = (S)-1,1′-bi-2-naphthol). The nature of the substituents on the nitrogen atom of the amide has a critical effect on the efficiency and selectivity of the reaction.