1021684-34-3Relevant articles and documents
Structure-activity relationships and CoMFA of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic properties
Palin, Ronald,Clark, John K.,Evans, Louise,Houghton, Andrea K.,Jones, Philip S.,Prosser, Alan,Wishart, Grant,Yoshiizumi, Kazuya
, p. 2829 - 2851 (2008/09/19)
The N-3 position of a series of 3-phenoxypropyl piperidine benzimidazol-2-one analogues was optimised using the predictive power of a CoMFA model. The model was used to prioritise compounds for synthesis culminating in the triazole (+)-24. (+)-24 was found to be a high affinity, potent NOP agonist and demonstrated both antinociceptive and antiallodynic effects when administered iv to rodents.