1021740-51-1

Basic information

• Product Name: 5-(5-chloro-thiophen-2-yl)-6-methyl-4-(2,4,6-trifluoro-phenyl)-2H-pyridazin-3-one
• Synonyms: 5-(5-chloro-thiophen-2-yl)-6-methyl-4-(2,4,6-trifluoro-phenyl)-2H-pyridazin-3-one
• CAS NO: 1021740-51-1
• Molecular Weight: 356.756
• Mol File: 1021740-51-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(5-chloro-thiophen-2-yl)-6-methyl-4-(2,4,6-trifluoro-phenyl)-2H-pyridazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(5-chloro-thiophen-2-yl)-6-methyl-4-(2,4,6-trifluoro-phenyl)-2H-pyridazin-3-one(1021740-51-1)
• EPA Substance Registry System: 5-(5-chloro-thiophen-2-yl)-6-methyl-4-(2,4,6-trifluoro-phenyl)-2H-pyridazin-3-one(1021740-51-1)

Safety Data

• Hazardous Substances Data: 1021740-51-1(Hazardous Substances Data)

Upstream product

• 63723-03-5 2-bromo-1-(5-chloro-thiophen-2-yl)-propan-1-one 
• 1374964-00-7 C₁₅H₈ClF₃O₂S 
• 1374963-99-1 C₁₅H₁₀ClF₃O₃S 
• 42518-98-9 5-chlorothiophene-2-carbonyl chloride 
• 24065-33-6 5-Chlorothiophene-2-carboxylic acid 
• 32427-82-0 1-(5-chloro-thiophen-2-yl)-propan-1-one 

Relevant articles and documents

Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: Pyridazines

Special tetrasubstituted pyridazines are potent fungicides by promoting the tubulin polymerisation, hereby disrupting the microtubule dynamics in the fungus. They are monocyclic analogs of similar substituted triazolopyrimidines and pyridopyrazines with the same mode of action. The fungicidal activity of these pyridazines was evaluated against the plant pathogens Botrytis cinerea (grey mould), Mycosphaerella graminicola (wheat leaf blotch) and Alternaria solani (potato and tomato early blight). Structure-activity relationship studies revealed the importance of a methyl and a chlorine substituent next to both ring nitrogen atoms and two aryl or heteroaryl groups in the other two pyridazine positions.