102245-02-3

Basic information

• Product Name: (Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE
• Synonyms: (Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE
• CAS NO: 102245-02-3
• Molecular Formula: C₁₂H₁₂ClNO₃
• Molecular Weight: 253.68158
• Mol File: 102245-02-3.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE(102245-02-3)
• EPA Substance Registry System: (Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE(102245-02-3)

Safety Data

• Hazardous Substances Data: 102245-02-3(Hazardous Substances Data)

Usage

Description

(Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE is an organic compound classified as an ester, characterized by its white solid appearance. It has a molecular formula of C13H12ClNO3 and a molecular weight of 259.69 g/mol. This versatile chemical is known for its potential in the synthesis of pharmaceuticals and agrochemicals, as well as its use as a building block for creating various biologically active compounds. Its ability to undergo reactions like hydrolysis, reduction, and addition allows for the formation of new compounds with different properties and applications, making it a valuable asset across multiple industries.

Uses

Used in Pharmaceutical Industry:
(Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE is used as a key intermediate for the synthesis of various pharmaceuticals. Its role in creating biologically active compounds contributes to the development of new medications with diverse therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, (Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE is utilized as a starting material for the production of different agrochemicals. Its versatility in chemical reactions enables the creation of compounds that can be used in pest control, crop protection, and other agricultural applications.
Used in Chemical Research and Development:
(Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE serves as a valuable compound in the field of chemical research and development. Its potential for modification and reaction with other substances makes it an ideal candidate for exploring new chemical pathways and creating innovative products with a wide range of applications.

Upstream product

• 108-24-7 acetic anhydride 
• 102244-86-0 (Z)-methyl 2-azido-3-(4-chlorophenyl)acrylate 
• 67-56-1 methanol 
• 93634-55-0 (Z)-4-(4-chlorobenzylidene)-2-methyloxazol-5(4H)-one 
• 106-39-8 bromochlorobenzene 
• 35356-70-8 Methyl 2-acetamidoacrylate 
• 104-88-1 4-chlorobenzaldehyde 
• 88681-63-4 (Z)-2-acetamido-3-(4-chlorophenyl)acrylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 124-41-4 sodium methylate 
• 543-24-8 N-acetylglycine 
• 93634-55-0 2-methyl-4-(4-chlorobenzylidene)-4H-oxazol-5-one 

Downstream Products

• 105962-47-8 cis-4-p-chlorophenyl-3-acetamido-3-carbomethoxy-Δ¹-pyrazoline 
• 93634-74-3 N-acetyl-(R)-3-(4-chlorophenyl)alanine methyl ester 
• 93634-74-3 methyl (S)-2-acetamido-3-(4-chlorophenyl)propanoate 
• 312300-60-0 methyl (E)-2-acetylamino-3-(4-chlorophenyl)-2-propenoate 
• 111016-47-8 4-(4-chlorophenyl)-1H-pyrazole 
• 111016-49-0 4-(4-chlorophenyl)-1H-pyrazole-3-carboxylic acid 
• 111016-44-5 4-(4-chloro-phenyl)-1⁽²⁾H-pyrazole-3-carboxylic acid methyl ester 
• 105962-35-4 methyl Z-2-acetamido-3-p-chlorophenyl-2-butanoate 
• 129496-71-5 methyl 2-acetylamino-3-(4-chlorophenyl)propanoate 

Relevant articles and documents

Concise synthesis and applications of enantiopure spirobiphenoxasilin-diol and its related chiral ligands

The development of chiral architectures for chiral ligand and catalyst discovery is essential for asymmetric catalysis. Herein, we report the concise synthesis of a Si-centered spirocyclic skeleton, spirobiphenoxasilin-diol (SPOSiOL), and its derived chiral ligands. Using the chemical resolution method, the optical SPOSiOL could be obtained in high yield on a gram scale. Preliminary studies indicated that this ligand scaffold has great potential in transition metal-catalyzed asymmetric reactions. This finding further highlights that the Si-centered spirocyclic scaffolds are of great value in asymmetric catalysis. This journal is

Ni(ii)-Catalyzed vinylic C-H functionalization of 2-acetamido-3-arylacrylates to access isotetronic acids

A ligand-free Ni(ii)-catalyzed cascade annulation reaction for the synthesis of 4-aryl-substituted isotetronic acids from 2-acetamido-3-arylacrylatesviavinylic C-H functionalization is reported. The reaction proceeds through heteroatom guided electrophilic insertion of nickel to the vinylic double bond followed by annulation with dibromomethane. This unconventional route features cascade steps, sole product formation, multiple functional group tolerance, low cost of catalysts and reagents, and readily available starting materials. Using this method, various aryl-substituted isotetronic acids have been synthesized which are biologically relevant. The annulation of 2-acetamido-3-arylacrylates has also been assessed with 1,2-dichloroethane, which resulted in the rearranged annulated products of 5-methyl substituted isotetronic acids.

Temperature-controlled bidirectional enantioselectivity in a dynamic catalyst for asymmetric hydrogenation

Asymmetric catalysis using enantiomerically pure catalysts is one of the most widely used methods for the preparation of enantiomerically pure compounds. The separate synthesis of both enantiomerically pure compounds requires tedious and time-consuming pr