102284-85-5

Basic information

• Product Name: Benzene, 2-azido-1,3-difluoro-
• CAS NO: 102284-85-5
• Molecular Formula: C6H3F2N3
• Molecular Weight: 155.107
• Mol File: 102284-85-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzene, 2-azido-1,3-difluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 2-azido-1,3-difluoro-(102284-85-5)
• EPA Substance Registry System: Benzene, 2-azido-1,3-difluoro-(102284-85-5)

Safety Data

• Hazardous Substances Data: 102284-85-5(Hazardous Substances Data)

Upstream product

• 5509-65-9 2,6-difluoroaniline 
• 85118-00-9 2,6-Difluorobenzyl bromide 
• 863868-37-5 2-(2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 155997-19-6 N-(2,6-Difluoro-phenyl)-4-methoxy-benzamide 
• 1448429-27-3 (2S,3S)-ethyl-3-((S)-1-((1-(2,6-difluorophenyl)-1H-1,2,3-triazol-4-yl)methylamino)-1-oxo-3-(thiazol-4-yl)propan-2-ylcarbamoyl)oxirane-2-carboxylate 
• 1270930-13-6 3',5'-di-O-acetyl-5-(1-[2,6-difluorophenyl]-1,2,3-triazol-5-yl)-2'-deoxyuridine 
• 1270929-91-3 3',5'-di-O-acetyl-5-(1-[2,6-difluorophenyl]-1,2,3-triazol-4-yl)-2'-deoxyuridine 
• 252750-46-2 2-[α-(5-amino-1-(2,6-difluorophenyl)-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester 
• 107253-50-9 2,6-difluorophenylnitrene 
• 5509-65-9 2,6-difluoroaniline 

Relevant articles and documents

Click Chemistry Derived Pyridazines: Electron-Deficient Building Blocks with Defined Conformation and Packing Structure

A series of 3,6-bis(4-triazolyl)pyridazines equipped with terminal phenyl substituents with varying degree of fluorination were synthesized by using the facile copper-catalyzed azide–alkyne cycloaddition and their structures were thoroughly investigated i

Alkyne-azide cycloaddition analogues of dehydrozingerone as potential anti-prostate cancer inhibitors: Via the PI3K/Akt/NF-kB pathway

Herein, we report the isolation and synthetic modification of dehydrozingerone (DHZ, 1), a secondary metabolite present in the rhizome of Zingiber officinale. We synthesized O-propargylated dehydrozingerone, which was subsequently coupled by alkyne-azide cycloaddition (3-20) using click chemistry. The compounds (1-20) were evaluated for their in vitro cytotoxic activity in a panel of three cancer cell lines. Among all the DHZ derivatives, 3, 6, 7, 8, 9 and 15 displayed potent cytotoxic potential with an IC50 value ranging from 1.8-3.0 μM in MCF-7, PC-3 and HCT-116 cell lines. Furthermore, compound 7 has proven to be the most potent cytotoxic compound in all the three distinct cancer cell lines and also demonstrated significant anti-invasive potential in prostate cancer. The mechanistic study of compound 7 showed that it not only suppressed the AKT/mTOR signalling which regulates nuclear transcription factor-NF-kB but also augmented the expression of anti-invasive markers E-cadherin and TIMP. Compound 7 significantly decreased the expression of pro-invasive markers vimentin, MMP-2 and MMP-9, respectively. This study underscores an efficient synthetic approach employed to evaluate the structure-activity relationship of dehydrozingerone (1) in search of potential new anticancer agents.

Mechanochemical Synthesis of Primary Amides

Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters with ethanol and calcium nitride afforded the corresponding primary amides in a transformation that was compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl. This methodology was applied to α-amino esters and N-BOC dipeptide esters and also to the synthesis of rufinamide, an antiepileptic drug.