1022931-45-8

Basic information

• Product Name: 1,4,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)PYRANO-[4,3-C]-PYRAZOLE
• Synonyms: 1,4,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)PYRANO-[4,3-C]-PYRAZOLE;3-(Trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole;4,6,7-Tetrahydro-3-(trifluoromethyl)pyrano-[4,3-c]-pyrazole
• CAS NO: 1022931-45-8
• Molecular Formula: C₇H₇F₃N₂O
• Molecular Weight: 192.14
• Mol File: 1022931-45-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 279℃
• Flash Point: 123℃
• Appearance: /
• Density: 1.451
• CAS DataBase Reference: 1,4,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)PYRANO-[4,3-C]-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)PYRANO-[4,3-C]-PYRAZOLE(1022931-45-8)
• EPA Substance Registry System: 1,4,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)PYRANO-[4,3-C]-PYRAZOLE(1022931-45-8)

Safety Data

• Hazardous Substances Data: 1022931-45-8(Hazardous Substances Data)

Usage

General Description

1,4,6,7-Tetrahydro-3-(trifluoromethyl)pyrano-[4,3-c]-pyrazole is a chemical compound that contains a pyrano-pyrazole structure with an embedded trifluoromethyl group. 1,4,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)PYRANO-[4,3-C]-PYRAZOLE has potential applications in the pharmaceutical industry due to its unique structure, which can potentially interact with biological receptors and enzymes in the human body. The presence of the trifluoromethyl group also imparts unique chemical and physical properties to the compound, making it valuable for medicinal and synthetic chemistry research. Further studies on this compound may lead to the development of new drugs or materials with specific properties and applications.

Upstream product

• 158351-87-2 3-(trifluoroacetyl)tetrahydro-4H-pyran-4-one 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 

Downstream Products

• 1138449-96-3 5-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione 
• 1022931-90-3 2-fluoro-4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]benzoic acid 
• 1022931-76-5 4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]benzoic acid 
• 1022930-30-8 1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole 
• 1022931-04-9 N-(tetrahydro-2-furanylmethyl)-4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]benzenesulfonamide 
• 1022930-33-1 1-({4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]phenyl}methyl)-2-pyrrolidinone 
• 1022930-95-5 1-[2-fluoro-4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole 
• 1022930-47-7 1-({2,6-difluoro-4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]phenyl}methyl)-2-pyrrolidinone 
• 1022931-18-5 1-{3-fluoro-4-[2-oxo-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole 
• 1022931-07-2 1-({2-fluoro-4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]phenyl}methyl)-2-pyrrolidinone 
• 1022930-85-3 N-({4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]phenyl}methyl)methanesulfonamide 

Relevant articles and documents

Integration of lead optimization with crystallography for a membrane-bound ion channel target: Discovery of a new class of AMPA receptor positive allosteric modulators

A novel series of AMPAR positive modulators is described that were identified by high throughput screening. The molecules of the series have been optimized from a high quality starting point hit to afford excellent developability, tolerability, and effica

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE

The invention provides compounds of formula (I) and salts thereof wherein R1, R2, R3, R4 and X are as defined in the description. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE

Compound of formula (I) and salts thereof are provided: wherein A, R1, R, R2 are as defined in the specification. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.