102317-07-7

Basic information

• Product Name: 3,3'-dimethoxy-4,4'-butanediyldioxy-di-benzonitrile
• CAS NO: 102317-07-7
• Molecular Weight: 352.39
• Mol File: 102317-07-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,3'-dimethoxy-4,4'-butanediyldioxy-di-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3'-dimethoxy-4,4'-butanediyldioxy-di-benzonitrile(102317-07-7)
• EPA Substance Registry System: 3,3'-dimethoxy-4,4'-butanediyldioxy-di-benzonitrile(102317-07-7)

Safety Data

• Hazardous Substances Data: 102317-07-7(Hazardous Substances Data)

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 

Downstream Products

• 125880-91-3 C₂₀H₂₆N₄O₄ 

Relevant articles and documents

Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia

A series of 33 analogues of the anti-Pneumocystis carinii drug 1,5-bis(4-amidinophenoxy)pentane (pentamidine) was synthesized for screening against a rat model of P. carinii pneumonia (PCP). Twenty-five of the compounds showed efficacy against PCP when compared to a saline-treated control group. Two compounds, 1,4-bis(4-amidinophenoxy)butane (butamidine, 6) and 1,3-bis(4-amidino-2-methoxyphenoxy)propane (DAMP, 16), were statistically more effective than the parent drug in treating PCP in the rat model of infection. In addition to their activity against PCP, the compounds were also evaluated for antitrypsin activity, ability to inhibit thymidylate synthetase, affinity for DNA, and toxicity. No correlation was observed between the tested molecular interactions of the diamidines and their effectiveness against PCP.